3/14/2013  Several studies have found that low levels of vitamin D are associated with increased mania, bi-polar disorder, depression, and psychosis.  More recently small studies suggest that in individuals with low levels, D3 supplements alone or in combination with prescribed psychiatric medications can improve mental status.  In a recent study by E Sikoglu et al. examining mania in teens with low levels of the blood variant of D3 (i.e., 25-OH-D) who also had low levels of the brain neurotransmitter GABA, an 8-week trial of D3 supplements significantly improved blood levels of 25-OH-D and brain GABA levels, and reduced manic symptoms.   (Finding summary from Bipolar Network News MARCH 12, 2013)